In collaboration with Dr. Ben Reubinoff at the Hadassah University Medical Center in Israel, on a project funded by the US-Israel Binational Science Foundation, PNR&D investigators are generating cellular models of both familial ALS and sporadic ALS using induced pluripotent stem cell (iPS) technology. Visit Stem cell research projects to read more about this project.
In collaboration with Drs. Frank C. Brosius, III, Matthias Kretzler, and H. V. Jagadish here at the University of Michigan, PNR&D investigators are examining the mechanisms behind diabetic complications. Using both human and animal model nerve and kidney tissues, investigators are using advanced systemic profiling to determine what causes diabetic complications in these tissues and identify new targets for therapeutic development. This collaborative project entitled “Integrated Systems Biology Approach to Diabetic Microvascular Complications” is funded by the NIH. Visit Systems biology approaches to understand diabetic complications to read more about this project.
In collaboration with Drs. Abcouwer, Antonetti, Brosius, Burant, Gardner, Jagadish, Kretzler and Pennathur here at the University of Michigan, PNR&D investigators are examining metabolic profiles that are associated with type 1 diabetes in the eye, nerve, and kidney. By determining which energy metabolism pathways are involved in the onset of complications in these susceptible tissues, comprehensive therapies may be developed. This Type 1 Diabetes Impact Award project collaboration entitled “Tissue-Specific Metabolic Reprogramming in Diabetic Complications“ is funded by the NIH. Visit Understanding metabolic responses in complication-prone tissues to read more about this project.