New Study shows how Diabetes Injures Nerves

In a new study soon to be published in the FASEB Journal, PNR&D scientist Gina Leinninger reports her newest results on neuronal survival in the face of high glucose. Ms. Leinninger, a current University of Michigan Graduate Student in the Neuroscience Program, has found that Insulin-like Growth Factor I (IGF-I) enhances the survival of those neurons affected in diabetic neuropathy using a specific survival pathway. Cells use this pathway to increase production of a group of factors that protect the cell from glucose-induced damage and death. This increased understanding of both how glucose kills neurons and the factors needed to protect them could lead to the identification of therapeutic targets in the future.