Archives for June 2016

Pesticide exposure may be risk factor for ALS

New research led by Program for Neurology Research & Discovery Director  Dr. Eva Feldman and other University of Michigan researchers shows environmental pollutants could affect the chances a person will develop amyotrophic lateral sclerosis, or ALS.

There is no cure for this rapidly progressive motor neuron disease, also known as Lou Gehrig’s disease. Those afflicted eventually lose their strength and ability to move their arms, legs and body.

As part of a larger study on environmental risk factors for ALS, U-M scientists published their work on pesticide and other environmental exposures in JAMA Neurology.

“From the first ALS patient I saw over 25 years ago to the ALS patient I diagnosed this week, I am always asked the same question, ‘Why me? What is different about my life that I got this disease?’” says Feldman, co-senior author of the study and a longtime ALS clinician and researcher. “I want to answer that question for my patients.”

Feldman’s team studied 156 people with ALS and 128 people without it. All described their exposure to pollutants at work and at home, with a focus on occupational exposure. The researchers also measured toxic persistent environmental pollutants in blood to gain a more comprehensive assessment of environmental exposures.

“We found these toxic chemicals in individuals both with and without ALS,” says co-first author Stephen Goutman, M.D., director of the U-M Comprehensive ALS Clinic. “We are likely all exposed without our own knowledge, from the air, water and our diet, as these chemicals can last decades in the environment. However, persons with ALS, overall, had higher concentrations of these chemicals, especially in regards to pesticides.”

There was no strong correlation, however, between any particular occupation and likelihood of developing ALS, except for service in the armed forces, a link found in previous studies.

Blood tests showed increased odds of ALS for those with exposure to several different types of chemicals, many of which are no longer widely used because of environmental concerns, such as the infamous pesticide DDT. Some of the classes of chemicals studied, however, such as polybrominated diphenyl ethers, used as flame retardants, have only experienced recent scrutiny as potential health hazards.

“The challenge is that persons are likely exposed to multiple chemicals and therefore it is too soon for us to know whether individual chemicals, or mixtures of chemicals, lead to motor neuron damage,” Goutman says. “Next, we will really dive into particular chemicals that could be risk factors for the disease.”

‘The first and very important step’

The researchers believe a better understanding of environmental risk factors for ALS could lead to an understanding of why persons develop ALS and also help to explain clusters of ALS cases in different geographical areas.

“This is the first and very important step to identifying what specific exposures are associated with ALS — to answering the ‘why me?’ question,” Feldman says. “Now it is time to understand how these exposures lead to disease with an eye to halting ALS onset. As one of my patients said to me before he died, we want a ‘world without ALS.’”

The Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry, the National Center for Research Resources and the National Center for Advancing Translational Sciences provided support for this research.

PNR&D director among Michigan’s “Influential Women”

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Eva Feldman, M.D., Ph.D., Director of the Program for Neurology Research & Discovery, is among the 100 most influential women in Michigan, according to a Crain’s Detroit Business special report.

The honorees include leaders in business, academia, nonprofits and public policy from across the state.

Feldman, a neurologist and leading ALS researcher, is the Russell N. DeJong Professor of Neurology, as well as Director of the A. Alfred Taubman Medical Research Institute at the University of Michigan. Crain’s touts her research team’s oversight of Phase 2 U.S. Food and Drug Administration trials treating ALS patients with injections of embryonic human stem cells.

Another distinguished U-M executive, Marianne Udow-Phillips, MHSA,also was named by Crain’s.  Udow-Phillips directs U-M’s Center for Healthcare Research & Transformation (CHRT). Crain’s highlights Udow-Phillips’ role in working with the state of Michigan and writing the winning grant for the 5-year, $110 million Michigan Primary Care Transformation demonstration project (MiPCT).

To read the full profiles of both women, or to view the full list of honorees, visit http://www.crainsdetroit.com/awards/mostinfluentialwomen/2016.