Archives for July 2015

Recent PNR&D publications

Scientists at the Program for Neurology Research & Discovery have had four scientific articles accepted by peer-reviewed journals since the beginning of May 2015, including:

Insulin resistance prevents AMPK-induced tau dephosphorylation through Akt-mediated increase in AMPKSer485 phosphorylation, in The Journal of Biological Chemistry. Authors Bhumsoo Kim, Claudia Figueroa-Romero, Crystal Pacut and Eva L. Feldman’s study linked obesity and diabetes with a greater risk of Alzheimer’s disease.

The Metabolic Syndrome and Microvascular Complications in a Murine Model of Type 2 Diabetes, in Diabetes. Authors Junguk Hur, Jacqueline R. Dauch, Lucy M. Hinder, John M. Hayes, Carrie Backus, S Pennathur, Matthias Kretzler MD and Frank C. Brosius, MD. This study demonstrated that small and large nerve fibers are affected by diabetes in different ways and may therefore require different potential therapies for diabetic nerve damage.

The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain, in Molecular Neurobiology. Researchers Catrina Sims-Robinson, Anna Bakeman, Andrew Rosko, Rebecca Glasser, and Eva L. Feldman, MD. Since lysosome dysfunction precedes neurodegeneration, cognitive deficits, and Alzheimer’s disease neuropathology, our results may provide a potential mechanism that links diabetes with complications of the central nervous system.

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era, in Nature Reviews Neurology. Researchers Ximena Paez-Colasante, Ph.D.; Claudia Figueroa-Romero, Stacey A. Sakowski, Stephen A. Goutman, MD; and Eva L. Feldman, MD, PhD, reviewed the latest findings regarding the role of miRNA modifications and other epigenetic mechanisms in ALS, and discussed their potential as therapeutic targets.

PNR&D scientists present at Peripheral Nerve Society

Eight researchers from the Program for Neurology Research & Discovery attended the Peripheral Nerve Society’s 2015 meeting, held June 28-July 2 in Quebec.

Postdoctoral Fellows Philippe O’Brian, Lucy Hinder and Amy Rumora presented posters. Also in attendance from PNRD&D were director Eva L. Feldman, M.D., Ph.D.; Brian C. Callaghan, M.D.; Samy Kashlan, John Hayes and Jacque Dauch.

Posters presented included:

Phillipe O’Brien:

‘Effect of Dietary Reversal on Peripheral Nerve Function in a Mouse Model of Pre-Diabetes’

Lucy Hinder:

Presentation I: ‘High-fat Diet-induced Metabolic Neuropathy: Effect of Mouse Strain’

Presentation II: ‘Shared Transcriptional Networks Between Diabetic Peripheral Neuropathy in Murine Models of Diabetes’

Amy Rumora: 

Presentation I: ‘Hyperlipidemia Alters Mitochondrial Trafficking in Dorsal Root Ganglion Sensory Neurons’

Presentation II: ‘Identification of a Tissue-Specific Effect of Pioglitazone Treatment on Gene Expression Profiles in a Murine Model of Type 2 Diabetes’

Brian C. Callaghan, M.D.:

‘The Association of Metabolic Syndrome Components with Polyneuropathy in an Obese Population’